Figure 1.

Probes to monitor mitochondrial Ca²⁺ signalling and mitophagy. The major molecular players regulating these functions are symbolized within mitochondria. Key imaging-based approaches are listed in the grey boxes in proximity to the corresponding mitochondrial function. MCU complex, mitochondrial Ca²⁺ uniporter complex; VDAC, voltage-dependent anion-selective channel proteins; PINK1, phosphatase and tension homologue (PTEN)-induced putative kinase 1; Parkin, E3 ligase PARK2; LC3, microtubule-associated protein 1 light chain 3; LAMP1, the lysosomal-associated membrane protein 1; AM, acetoxymethyl ester; GECIs, genetically-encoded Ca²⁺ indicators; FPs, fluorescent proteins; GE, genetically-encoded. The figure was generated with elements provided in the Servier Medical Art depository (https://smart.servier.com/) and are licensed under a Creative Commons Attribution 3.0 Unported License (CC BY 3.0).