Table 5.
Single physiological variables or inflammatory biomarkers as predictors of AT surgical cure in the pediatric OSA patients.
| Predictors | Cut-off Value | AUC | 95% CI | p-Value |
|---|---|---|---|---|
| Clinical variables | ||||
| Age (years) | <7.0 | 0.70 | 0.57–0.84 | 0.01 |
| Boys | Boy | 0.42 | 0.27–0.56 | 0.28 |
| BMI (kg/m2) z-score | <1.44 | 0.74 | 0.61–0.87 | 0.002 |
| OSA-18 | >78.5 | 0.53 | 0.38–0.68 | 0.69 |
| OAHI (events/h) | <4.0 | 0.63 | 0.49–0.77 | 0.09 |
| OAI (events/h) | >0.6 | 0.59 | 0.44–0.74 | 0.25 |
| Mean SpO2 (%) | >97.6 | 0.61 | 0.46–0.75 | 0.18 |
| Minimum SpO2 (%) | >86.5 | 0.58 | 0.43–0.73 | 0.29 |
| Inflammatory biomarkers | ||||
| IL-1β (pg/mL) | >0.3 | 0.56 | 0.41–0.71 | 0.41 |
| IL-1ra (pg/mL) | <149.2 | 0.67 | 0.53–0.81 | 0.03 |
| IL-2 (pg/mL) | >3.4 | 0.62 | 0.48–0.77 | 0.11 |
| IL-4 (pg/mL) | >1.8 | 0.62 | 0.46–0.77 | 0.14 |
| IL-5 (pg/mL) | >1.0 | 0.62 | 0.47–0.77 | 0.12 |
| IL-6 (pg/mL) | <2.0 | 0.55 | 0.40–0.70 | 0.49 |
| IL-7 (pg/mL) | >4.9 | 0.59 | 0.44–0.74 | 0.24 |
| IL-8 (pg/mL) | >3.0 | 0.62 | 0.46–0.77 | 0.13 |
| IL-9 (pg/mL) | >82.8 | 0.67 | 0.52–0.82 | 0.03 |
| IL-10 (pg/mL) | <0.5 | 0.69 | 0.55–0.83 | 0.01 |
| IL-12 (pg/mL) | >0.2 | 0.63 | 0.48–0.78 | 0.10 |
| IL-13 (pg/mL) | <1.4 | 0.58 | 0.43–0.73 | 0.31 |
| IL-15 (pg/mL) | <11.8 | 0.71 | 0.58–0.84 | 0.01 |
| IL-17 (pg/mL) | >4.7 | 0.66 | 0.51–0.81 | 0.04 |
| Eotaxin (pg/mL) | >36.8 | 0.61 | 0.45–0.76 | 0.17 |
| Basic-FGF (pg/mL) | >15.9 | 0.65 | 0.50–0.80 | 0.06 |
| G-CSF (pg/mL) | >69.5 | 0.64 | 0.50–0.78 | 0.07 |
| GM-CSF (pg/mL) | <0.2 | 0.68 | 0.54–0.81 | 0.02 |
| Interferon-γ (pg/mL) | >1.9 | 0.51 | 0.36–0.66 | 0.91 |
| IP-10 (pg/mL) | <818.6 | 0.56 | 0.41–0.71 | 0.45 |
| MCP-1 (pg/mL) | <51.2 | 0.67 | 0.52–0.82 | 0.03 |
| MIP-1α (pg/mL) | <1.2 | 0.51 | 0.36–0.66 | 0.87 |
| MIP-1β (pg/mL) | <121.6 | 0.53 | 0.38–0.68 | 0.74 |
| PDGF-BB (pg/mL) | <10201.7 | 0.62 | 0.46–0.77 | 0.13 |
| RANTES (pg/mL) | >15435.5 | 0.71 | 0.56–0.85 | 0.01 |
| TNF-α (pg/mL) | >27.9 | 0.65 | 0.50–0.80 | 0.06 |
| VEGF (pg/mL) | <42.1 | 0.70 | 0.57–0.84 | 0.01 |
Abbreviations: AUC: area under the curve; BMI: body mass index; CI: confidence interval; FGF: fibroblast growth factor; G-CSF: granulocyte-colony stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; IL: interleukin; IP: interferon gamma-induced protein; MCP: monocyte chemotactic protein; MIP: macrophage inflammatory protein; OAHI: apnea–hypopnea index; OAI: apnea index; OSA: obstructive sleep apnea; PDGF: platelet-derived growth factor; RANTES: regulated on activation, normal T cell expressed and secreted; SpO2: oxygen saturation measured by pulse oximetry; TNF: tumor necrosis factor; VEGF: vascular endothelial growth factor.