Table 3.

Cox regression models assessing the potential of clinical and VIMme and miR663ame levels in the prediction of disease-specific survival for bladder carcinoma (BlCa) patients.

Disease-specific Survival	Variables	Hazard Ratio (HR)	95% CI for OR	p
Univariate	Invasion of muscular layer	6.15	2.76–13.72	0.0001
	Grade
	PLG vs. PHG	15.59	2.03–119.94	0.008
	PLG vs. IHG	32.83	4.31–250.06	0.001
	Age	2.34	0.98–5.59	0.060
	Gender	1.02	0.39–2.70	0.970
	miR663a methylation ≤ median	1.61	0.75–3.48	0.225
	VIM methylation ≤ median	1.07	0.50–2.28	0.861
Multivariate	Invasion of muscular layer	3.54	1.12–11.19	0.031
	Grade
	PLG vs. PHG	8.03	0.97–66.32	0.053
	PLG vs. IHG	11.89	1.18–119.37	0.035
	miR663a methylation ≤ median	2.67	1.05–6.81	0.040
	VIM methylation ≤ median	1.12	0.51–2.42	0.783

CI—confidence interval; OR—odds ratio; PLG—papillary low-grade; PHG—papillary high-grade; IHG—invasive high-grade.