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. 2020 Feb 14;9(2):528. doi: 10.3390/jcm9020528

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Drug release from fibrin glue. (1) Fibrin glue (FG) layers formed with incorporated drug overlaid with culture medium. (2) Supernatant harvested at different times from drug containing FG layers co-cultured with spheroids formed from glioma cells pre cultured with photosensitizer in the (3) absence or (4) presence of light treatment (PCI). Spheroid growth was monitored for 14 days. (B) Proposed clinical translation of FG-PCI protocol. Following tumor resection, the resection cavity is filled with drug/photosensitizer loaded FG. The FG slowly dissolves releasing the drug. Light treatment done through a temporarily surgically placed optical fiber positioned in the center of FG insert.