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. 2020 Feb 14;9(2):528. doi: 10.3390/jcm9020528

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pharmacokinetic analyses of plasma concentration of TPCS_2a. The concentration of TPCS_2a in plasma samples from patients in the dose cohorts 0.25–1.5 mg/kg was analyzed by fluorescence spectroscopy. The excretion rate of TPCS2a in the 0.25 mg/kg cohort that was regarded as the optimal treatment dose was found to fit well a two-compartment model: f(x) = 4.43e^−4.71x + 1.69e^−0.69x (R² = 0.99) as presented in the figure. The figure is modified from previously presented results [106]. Error bars show SD.