Sixty-one-year-old female with metastatic squamous cell carcinoma (SCC) to the torso (back) treated with PCI of bleomycin. The primary identified disease was in the tongue base with nodal involvement (cervical and axillary). The patient underwent radiotherapy and multiple rounds of chemotherapy for her tongue base carcinoma, which failed to control the disease. Left-hand column: the shielding around the lesion after including 10mm of macroscopically healthy looking tissue to eliminate any risk of micro-infiltration, followed by PCI surface illumination. Right hand column: the “target lesion” on day -14, day 28 and month 3, where complete response was achieved. For month 3, selective surgical biopsies acquired from the centre and peripheries were found to be tumour-free.