Figure 1.

Drawbacks and future potentials in targeting Akt with small molecules in the clinic. Overview of protein kinase Akt in the inactive conformation and addressable binding cavities for inhibition: active site (yellow), PIP₃-binding domain (red), and allosteric pocket (blue) (merged PDB-structures: 5KCV, 4GV1, 2UVM, and 6HHF).