Table 3. Pharmacokinetic Parameters of 72c in Mice.

	72c	8a
Dose 20 mg/kg iv
AUC0–last (μM·min/mL)	1790	3140
AUC0–∞ (μM·min/mL)	2570	3520
CL (mL/min/kg)	7.8	5.7
Vd (L/kg)	14.2	4.7
t1/2 dist (h)	0.4	0.009
t1/2 elim (h)	21.1	9.6
Dose 20 mg/kg po
AUC0–last (μM·min/mL)	718	3060
AUC0–∞ (μM·min/mL)	1040	4060
Cmax (μg/mL)	1.0	2.3
Tmax (h)	2.5	6
t1/2 abs (h)	1.3	0.8
t1/2 dist (h)	6.2	15.9
t1/2 elim (h)	17.0	18.6
F (%)	41	97

^aData from Spink et al., reproduced for comparison