Table 1. Targeted in Vitro and in Vivo Properties for Antischistosomal Lead Compounds.

	property	suggested minimum value or threshold
in vitro bioactivity and selectivity properties	S. mansoni severity score	at 10 μM ≥ 2 after 5 h or ≥ 3 after 24 h
	HepG2 TC50	≥ 5 μM after 48 h
in vitro ADME properties	human liver microsome clearance	Clint < 8.6 μL/min/mg protein
	rat hepatocyte clearance	Clint < 5.1 μL/min/106 cells
	plasma protein binding (PPB)	< 95%
	thermodynamic solubility (pH = 7)	> 100 μM