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Schematic of microRNA (miR)-27a* regulation in head and neck squamous cell carcinoma (HNSCC). ΔNp63α transcriptionally upregulates miR-27a*. ΔNp63α is a direct target of miR-27a*, forming a feedback loop. NUP62 regulates ΔNp63α protein transport into the nucleus and is a direct target of miR-27a*. Mutant TP53 disrupts the ΔNp63α-miR-27a* autoregulatory loop by repressing miR-27a*.
