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. 2019 Dec 12;63(5):2028–2034. doi: 10.1021/acs.jmedchem.9b01546

Figure 2.

Figure 2

(a) Expression of CYP3A4 in lysates from KCL22 and KCL22Pon-Res cells. β-actin was used as a loading control. (b) Ponatinib and ponatinib metabolites identified by LC-MS. Cells were treated with ponatinib for 1 h prior to analysis. Mean values from five biological repeats expressed relative to ponatinib.