Scheme 1. General Route to Sulfur-Linked 2,5-AMTz Analogues.
Reagents and conditions: (a) Pd2dba3, XantPhos, NaOtBu, PhMe, tBuOH, 110 °C; (b) Pd2dba3, XantPhos, DIPEA, PhMe, 110 °C; (c) m-CPBA, DCM, rt; (d) 4 M HCl in dioxane, rt.
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