Comparison 5. Pharmacological cooling by duration of therapy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death or dependency	7	291	Odds Ratio (M‐H, Fixed, 95% CI)	0.93 [0.57, 1.50]
1.1 Treatment during 24 hours	1	39	Odds Ratio (M‐H, Fixed, 95% CI)	1.08 [0.28, 4.20]
1.2 Treatment during 3 days	1	60	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.36, 2.77]
1.3 Treatment during 5 days	5	192	Odds Ratio (M‐H, Fixed, 95% CI)	0.88 [0.48, 1.60]
2 Death	7	291	Odds Ratio (M‐H, Fixed, 95% CI)	1.16 [0.45, 3.02]
2.1 Treatment during 24 hours	1	39	Odds Ratio (M‐H, Fixed, 95% CI)	0.95 [0.06, 16.31]
2.2 Treatment during 3 days	1	60	Odds Ratio (M‐H, Fixed, 95% CI)	0.71 [0.17, 2.96]
2.3 Treatment during 5 days	5	192	Odds Ratio (M‐H, Fixed, 95% CI)	2.07 [0.43, 10.07]