Comparison 6. Pharmacological cooling by type of treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death or dependency mRS ≥ 3	7	280	Odds Ratio (M‐H, Fixed, 95% CI)	0.89 [0.54, 1.48]
1.1 Paracetamol	5	184	Odds Ratio (M‐H, Fixed, 95% CI)	0.92 [0.48, 1.75]
1.2 Metamizol	1	60	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.36, 2.77]
1.3 Ibuprofen	1	36	Odds Ratio (M‐H, Fixed, 95% CI)	0.6 [0.15, 2.44]
2 Death	7	291	Odds Ratio (M‐H, Fixed, 95% CI)	1.16 [0.45, 3.02]
2.1 Paracetamol	5	195	Odds Ratio (M‐H, Fixed, 95% CI)	1.75 [0.45, 6.82]
2.2 Metamizol	1	60	Odds Ratio (M‐H, Fixed, 95% CI)	0.71 [0.17, 2.96]
2.3 Ibuprofen	1	36	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]