| Methods |
Randomised, computer‐generated random numbers
Blinding: double blind
Placebo controlled
Losses to follow up: 0 |
| Participants |
Patients with acute ischaemic anterior circulation stroke < 24 hours of symptom onset
50 participants (high dose 26, placebo 24)
Mean age ( SD): high dose paracetamol 69 years (13 years), placebo 68 years (15 years)
28 male (56%)
Stroke severity: (NIHSS) mean (SD) high dose paracetamol 8.8 (5.6), placebo 8.8 (5.4)
Body temperature was measured by both tympanic and rectal thermometers |
| Interventions |
Paracetamol 1000 mg suppository 6 times daily
Control: placebo
Duration: 5 days |
| Outcomes |
Body temperature
Death or dependency (mRS ≥ 3) at 1 month
Death at 1 month
Intracranial/extracranial haemorrhage/haemorrhagic transformation of infarction
Infections
Other side effects: deep venous thrombosis, cardiac arrhythmias |
| Notes |
Two intervention groups: we divided the number of participants with poor outcome and the total number of participants in the control group by 2 in order to avoid multiple comparisons using the same subset of participants |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
