Krieger 2001.

Methods	Eligible patients screened during the study period who were not enrolled served as concurrent controls Blinding: none Losses to follow up: none Intention to treat: unknown
Participants	Patients with a clinical diagnosis of acute ischaemic middle cerebral artery territory stroke Eligible for intravenous thrombolysis or intra‐arterial thrombolysis/thrombectomy and the initiation of moderate hypothermia within 5 hours of symptom onset (for patients treated with intravenous thrombolysis) or 8 hours after symptom onset (for patients treated with intra‐arterial thrombolysis) Mean age (SD) cooling blanket 71.1 years (14.3 years), control 68.2 years (12.3 years) 19 participants 10 male (53%) Stroke severity: (NIHSS) mean (SD) cooling blanket 19.8 (3.3), control 19.6 (2.6) Body temperature was measured in the bladder
Interventions	Cooling blanket (Aquamatic K‐Thermia EC600); ice water and whole body alcohol rubs were applied concurrently Control: none Duration: 12 to 72 hours
Outcomes	Body temperature Death or dependency (mRS ≥ 3) at 3 months Death at 3 months Intracranial/extracranial haemorrhage/haemorrhagic transformation of infarction Infections Other side effects: cardiac arrhythmias and hypotension
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	High risk	C ‐ Inadequate

SD: standard deviation 
 SSS: Scandinavian Stroke Scale 
 mRS: modified Rankin Scale 
 NIHSS: National Institutes of Health Stroke Scale