van Breda 2005.

Trial name or title	PAIS: Paracetamol (acetaminophen) in stroke
Methods	Multicenter, randomised, double‐blind, placebo‐controlled trial
Participants	Acute stroke patients Inclusion ≤ 12 hours from stroke onset
Interventions	Paracetamol, daily dose 6 g or placebo
Outcomes	mRS at 3 months BI at 3 months, EuroQol‐5D and body temperature at 24 hours from start of treatment The primary effect estimate is the odds ratio of improvement on the mRS according to the sliding dichotomy approach Secondary effect analyses are an estimate of the odds ratio for improvement assessed by means of ordinal logistic regression analysis, and the dichotomized mRS (≤ 2: good outcome, > 2: poor outcome)
Starting date	2003
Contact information	Heleen den Hertog, email: m.denhertog@erasmusmc.nl
Notes	1383 participants were included Follow up will be completed on 1 August 2008.

BI: Barthel Index 
 mRS: modified Rankin Scale 
 tPA: tissue plasminogen activator