Castillo 2003.

Methods	Randomised, method not stated Blinding: double‐blind Placebo‐controlled trial Losses to follow up: 0 Intention to treat: yes
Participants	Patients with acute ischaemic stroke ≤ 24 hours of symptom onset Admission body temperature between 37 and 38 degrees 60 participants Mean age (SD) metamizole 71 years (10 years), placebo 70 years (11 years) 24 male (40%) Stroke severity: (SSS) mean (SD) metamizole 27.2 (8.6), placebo 28.9 (10.5) Body temperature was measured using a tympanic thermometer
Interventions	Metamizole 2 g 3 times daily Control: placebo Duration: 3 days
Outcomes	Death or dependency (mRS ≥ 3) at 1 month Death at 1 month Infections Other side effects
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate