De Georgia 2004.

Methods	Randomised, using sealed envelopes Blinding: none Controlled Losses to follow up: none Intention to treat: yes
Participants	Patients with acute ischaemic anterior circulation stroke < 24 hours of symptom onset 40 participants Mean age (SD) endovascular cooling 61 years (12 years), control 67 years (13 years) 19 male (48%) Stroke severity: (NIHSS) mean (SD) treatment 16 (4), control 14 (5) In the intervention group oesophageal temperatures were monitored Bladder or rectal temperatures were monitored in the control group
Interventions	Endovascular cooling using the Reprieve Endovascular Temperature Management System Control: standard treatment Duration: 24 hours
Outcomes	Body temperature Death or dependency (mRS ≥ 3) at 1 month Death at 1 month Intracranial/extracranial haemorrhage/haemorrhagic transformation of infarction Infections Other side effects
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A‐ adequate