Table 4.
Association between plasma vitamin B12 ≥ 1000 ng/L and solid cancers according to cancer and metastatic sites in multivariate analysis.
| Adjusted OR * [95%CI] | p-value | |
|---|---|---|
| A—Sites of solid cancers † | ||
| Colon and rectum | 3.02 [1.35–6.75] | 0.007 |
| Liver | 1.46 [0.30–7.15] | 0.64 |
| Pancreas | 4.00 [1.02–15.65] | 0.04 |
| Skin | 2.62 [0.49–13.92] | 0.26 |
| Lungs | 2.89 [1.14–7.35] | 0.03 |
| Prostate | 2.17 [1.02–4.63] | 0.04 |
| Kidneys | 0.31 [0.06–1.66] | 0.17 |
| Breasts | 1.86 [0.77–4.47] | 0.17 |
| Urothelium | 7.40 [1.77–30.87] | 0.006 |
| Uterus (body/neck) and ovaries | 1.07 [0.30–3.82] | 0.91 |
| Esophagus and stomach | 3.47 [0.69–17.49] | 0.13 |
| Others | 14.94 [3.89–57.3] | <10−4 |
| B—Sites of metastases † | ||
| Brain | 0.57 [0.14–2.30] | 0.43 |
| Liver | 4.88 [2.16–11.00] | <10−4 |
| Bones | 3.11 [1.33–7.27] | 0.009 |
| Lungs | 2.10 [0.76–5.82] | 0.15 |
| Lymph nodes | 2.58 [0.94–7.07] | 0.07 |
| Others | 0.59 [0.22–1.58] | 0.29 |
* Adjustment for sex, age, chronic and acute liver diseases, severe chronic kidney failure, autoimmune and inflammatory diseases, excessive vitamin B12 supplementation, myeloid and lymphoid blood malignancies. † The conditional logistic regression models of items A and B are independent. However, all variables listed under each item are included in the models as well as age, sex, and comorbidities.