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. 2020 Jan 22;9(2):317. doi: 10.3390/jcm9020317

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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High-fat, high-sucrose (HFHS) diet increased retinal levels of tyrosine nitration and lipid peroxidation and this was prevented with arginase 2 (A2) deletion. Representative western blots and quantitation of 3-nitrotyrosine (3-NT) (n = 3–4 per group) (A,B) from same membrane as Figure 1A and 4-hydroxynoneal (4HNE) (n = 4 per group) (C,D) levels in retinas. Retinas from A2^−/− groups showed no elevation of 3-NT or 4HNE. Data are presented as mean ± SEM. * p < 0.05 compared to ND-fed mice of same genotype, # p < 0.05 compared to wild-type (WT) mice on same diet.

High-fat, high-sucrose (HFHS) diet increased retinal levels of tyrosine nitration and lipid peroxidation and this was prevented with arginase 2 (A2) deletion. Representative western blots and quantitation of 3-nitrotyrosine (3-NT) (n = 3–4 per group) (A,B) from same membrane as Figure 1A and 4-hydroxynoneal (4HNE) (n = 4 per group) (C,D) levels in retinas. Retinas from A2^−/− groups showed no elevation of 3-NT or 4HNE. Data are presented as mean ± SEM. * p < 0.05 compared to ND-fed mice of same genotype, # p < 0.05 compared to wild-type (WT) mice on same diet.