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. 2020 Jan 22;9(2):317. doi: 10.3390/jcm9020317

Figure 3.

Figure 3

Arginase 2 (A2) deletion prevented high-fat, high-sucrose (HFHS) diet-induced inflammasome activation. Representative western blot (A) with quantitation showing the effect of HFHS and A2 deletion on the expression of nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain-containing protein 3 (NLRP3)) (B), pro-interleukin-1β (pro-IL-1β) (C), poly [ADP-ribose] polymerase 1 (PARP1) (D), active (cleaved) PARP1 (E), procaspase 1 (F) and caspase 1 (G) (n = 5–6 per group). Data are presented as mean ± SEM (standard error of the mean). * p < 0.05 when compared to normal diet (ND)-fed mice of the same genotype, # p < 0.05 when compared to wild-type (WT) mice on the same diet.