Table 2.

Treatment of patients with CTD related ILD. Summary of the literature according to the study design.

	Systemic Sclerosis	Idiopathic Inflammatory Myopathy	Primary Sjogren Syndrome	Systemic Lupus Erythematosus
Glucocorticoids	Prospective [171] Nested case control [38] Retrospective [34]	Prospective [89] Retrospective [98,100,101,112]
Cyclophosphamide	Randomized clinical trial [9,10,11,12,13,15,40] Prospective [171] Retrospective [34,41,50,52]	Prospective [89] Retrospective [79,88,91,115]
Mycophenolate Mofetil	Randomized clinical trial [13,14] Prospective [45] Retrospective [34,43,44,46,47,48,51]	Retrospective [79,92,93]
Azathioprine	Randomized clinical trial [12,15] Retrospective [34,50]	Prospective [89] Retrospective [79]
Rituximab	Randomized clinical trial [16,17] Prospective [57,59] Nested case control [54] Retrospective [53,55,56,58]	Randomized clinical trial [29] Retrospective [119,120,121,122,123,125] Case report [109,115]	Prospective [143] Retrospective [145] Case report [136]
Hematopoietic stem cells transplantation	Randomized clinical trial [18,19,20]
Tyrosine kinase inhibitors	Randomized clinical trial [21,22,23,24,72]
Pirfenidone	Randomized clinical trial [25,26] Prospective [73] Retrospective [74]			Case report [150]
Calcineurin inhibitors		Prospective [106] Retrospective [81,97,98,99,100,102,107,108,109,110,112,114,115,117]
Lung transplantation	Retrospective [61,63,64,65,66,67,68,69,70]	Retrospective [133,134,135] Case report [131,132]
Plasma exchange		Case report [129,130]
Intravenous Immunoglobulins		Retrospective [126,128] Case report [127]
IL-6 inhibitors	Randomized clinical trial [27,28]		Case report [146]
Methotrexate		Prospective [89]

IL: interleukin.