Table 1.
Inhibition of cancer cell proliferation by asperphenins and synthetic derivatives.
| Compounds | IC50 (µM), 72 h | |||
|---|---|---|---|---|
| RKO | SNU638 | SK-HEP-1 | MDA-MB-231 | |
| Asperphenin A (1) | 0.84 ± 0.26 | 4.31 ± 0.83 | 2.89 ± 0.03 | 6.48 ± 0.74 |
| Asperphenin B (2) | 1.26 ± 0.43 | 7.59 ± 1.77 | 3.08 ± 0.18 | 9.43 ± 0.39 |
| Cycloasperphenin A (3) | >50 | >50 | >50 | >50 |
| Cycloasperphenin B (4) | >50 | >50 | >50 | >50 |
| 7-Hydroxyasperphenin A (5) | 24.23 ± 1.05 | 42.55 ± 4.59 | 37.58 ± 0.96 | >50 |
| 7-epi-Hydroxyasperphenin A (6) | 28.12 ± 4.36 | 49.26 ± 0.93 | 40.93 ± 0.66 | >50 |
| 7-Hydroxyasperphenin B (7) | 36.32 ± 1.45 | 42.40 ± 1.27 | 48.09 ± 0.01 | >50 |
| 7-epi-Hydroxyasperphenin B (8) | 27.75 ± 2.98 | >50 | >50 | >50 |
| 7,15(S)-Dihydroxyasperphenin A (9) | >50 | >50 | >50 | >50 |
| 7,15(S)-Dihydroxyasperphenin B (10) | >50 | >50 | >50 | >50 |
| 7,15(R)-Dihydroxyasperphenin B (11) | >50 | >50 | >50 | >50 |
| Etoposide 1 | 3.82 ± 0.74 | 0.30 ± 0.05 | 0.49 ± 0.12 | 10.72 ± 0.88 |
1 Etoposide was used as a positive control.