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. 2020 Feb 1;9(2):396. doi: 10.3390/jcm9020396

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Glycosaminoglycans (GAGs) levels in the brains of mucopolysaccharidosis patients and controls. Levels of disaccharides produced by enzymatic digestion of dermatan sulfate (DS) (ΔDi-0S, ΔDiHS-NS) and heparan sulfate (HS) (ΔDiHS-0S) as well as mono-sulfated and di-sulfated keratan sulfate (KS) were measured by tandem mass spectrometry and expressed (A) for the individual MPS patients and controls or (B) grouped according to the type of MPS disorder. Statistical significance of changes was estimated using Mann–Whitney multiple comparison test. Arrows indicate values detected in the tissues of non-neurological MPS II patient 902.