Table 4.

Independent determinants of urinary 2Py/N¹-MN in RTR.

Variable	Univariable		Multivariable 1
	Standardized β	p-Value	Standardized β	p-Value
Age, years	0.03	0.09	-	-
Male, n (%)	−0.004	0.92	-	-
BMI, kg/m2	0.17	<0.001	-	-
Time since transplantation, years	−0.07	0.07	-	-
Lifestyle
Current smoker, n (%)	−0.10	0.02	−0.13	0.001
Alcohol consumption, g/day	−0.15	<0.001	−0.12	0.002
Nutrition
Energy intake, kcal/day	−0.09	0.03	-	-
Niacin equivalents intake, mg/day	−0.06	0.14	-	-
Vitamin B6 intake, mg/day	−0.09	0.03	-	-
Glucose homeostasis
Diabetes, n (%)	0.16	<0.001	0.10	0.01
Lipid homeostasis
LDL, mmol/L	0.07	0.10	-	-
HDL, mmol/L	−0.20	<0.001	−0.12	0.002
Hemodynamic
Mean arterial pressure, mmHg	0.10	0.02	-	-
Inflammation
Hs-CRP, mg/L	0.19	<0.001	0.10	0.009
Kidney function
eGFR, mL/min/1.73 m2	−0.40	<0.001	−0.38	<0.001
Proteinuria, n (%)	0.08	0.04	-	-
Nonimmunosuppressive medication
Antihypertensive, n (%)	0.09	0.02	-	-
Acetylsalicylic acid, n (%)	0.09	0.03	-	-
Proton pump inhibitor, n (%)	0.08	0.04	-	-
Immunosuppressive medication
Prednisolon dose, mg/day	0.07	0.07	-	-
Tacrolimus, n (%)	0.11	0.007	-	-
R 2	0.28		0.26
Adjusted R2	0.25		0.25

¹ Stepwise multivariable linear regression with backward elimination was performed to identify determinants of urinary 2Py/N¹-MN, of which standardized β and p-value are presented. BMI, body mass index; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; hs-CRP, high-sensitivity C-reactive protein; LDL, low-density lipoprotein; N¹-MN, N¹-methylnicotinamide; RTR, renal transplant recipients; 2Py, N¹-methyl-2-pyridone-5-carboxamide; 2Py/N¹-MN, ratio of 2Py to N¹-MN.