Table 1.
Comparison of ACT and DOAC concentration between treatment groups.
| INR | DOAC Concentration (ng/mL) | ACT (seconds) | |
|---|---|---|---|
| Control (n = 25) | - | - | 133 (12.0) # † ‡ § |
| VKA (n = 24) | 2.2 (0.6) | - | 178 (31.9) * † § |
| Apixaban (n = 25) | - | 174 (115) | 152 (19.3) * # ‡ § |
| Rivaroxaban (n = 25) | - | 213 (133) | 178 (31.9) * † § |
| Dabigatran (n = 25) | - | 158 (98) | 195 (29.4) * # † ‡ |
* p < 0.05 when compared to control; † p < 0.05 when compared to apixaban; ‡ p < 0.05 when compared to rivaroxaban; § p < 0.05 when compared to dabigatran; # p < 0.05 when compared to VKA. Results are expressed in mean (standard deviation). ACT: activated clotting time; DOAC: direct oral anticoagulant; INR: international Normalized Ratio.