Figure 5.

PC inhibitor controlled the balance between lactate dehydrogenase (LDH) and pyruvate dehydrogenase (PDH) in PAH. (A) Lactate dehydrogenase (LDHA) increased in the SU5 group was significantly reduced with PC inhibitor treatment. (B) Total PDH expression was not significantly altered, but (C) PDH activity significantly attenuated in the SU5 PAH group, and PC inhibitor treatment reduced this back to the control level. Data expressed as box-and-whisker plot with median value ± min max, * p < 0.05 versus control, # p < 0.05 versus SU5 by ANOVA.