Table 1:

The characterization of selected gene prioritization tools.

	strategy		approach type		interfaces		input
	integrate gene-disease associations	search for genes associated with seeds	score aggregation	network analysis	web interface	programmatic access	seed genes	disease or phenotype terms	candidate genes
DisGeNET [34]	+		+		+	+	no	yes	whole genome
GLAD4U [36]	+		+		+		no	yes	whole genome
Genie [35]	+		+		+		no	yes	optional
OpenTargets [32]	+		+		+	+	no	yes	optional
Polysearch [30]	+		+		+		no	yes	whole genome
Phenolyzer [33]	+	+	+		+	+	no	yes	optional
PhenoRank [31]	+	+		+		+	no	yes	whole genome
Endeavour [39]		+	+		+		yes	no	yes
GeneMANIA [37]		+		+	+	+	yes	no	whole genome
GPS [42]		+	+	+	+		yes	no	yes
MaxLink [51]		+		+	+		yes	no	whole genome
pBRIT [85]		+	+		+	+	yes	no	yes
ToppGene [83]		+	+		+		yes	no	yes
ToppNet [74]		+		+	+		yes	no	yes