Figure 1.

Association of grey matter volume and developmental quotient (DQ). A, Change in gray matter volume for the rapid progressing (RP) and slow progressing (SP) groups of MPS IIIA patients by age. B, Association of decline in developmental quotient and gray matter volume for the RP and SP groups. Open circles indicate the imputed values, which are connected with dotted lines (values imputed from slope of previous visits) for 4 patients at the 24-month visit only and for 1 patient at both the 12-month and 24-month visits (figure reproduced from Shapiro et al., 2016 [37], with permission from Elsevier).