Table 2.
Determinants of stroke and major bleeding events in a multivariate Cox regression model.
| Item | Stroke | Major Bleeding | ||
|---|---|---|---|---|
| HR (95% C.I.) | p Value | HR (95% C.I.) | p Value | |
| Age ≥ 75 years | 1.36 (0.88–2.08) | 0.15 | 1.16 (0.76–1.76) | 0.48 |
| Male | 1.11 (0.71–1.80) | 0.63 | 1.33 (0.83–2.19) | 0.23 |
| Body weight ≤ 50 kg | 1.11 (0.63–1.89) | 0.70 | 0.96 (0.53–1.69) | 0.91 |
| Persistent AF or LS-AF vs. Paroxysmal AF | 1.46 (0.97–2.24) | 0.069 | 1.10 (0.74–1.66) | 0.60 |
| Hypertension | 1.28 (0.83–2.03) | 0.26 | 1.29 (0.84–2.04) | 0.24 |
| Diabetes mellitus | 1.05 (0.67–1.61) | 0.79 | 1.31 (0.86–1.95) | 0.19 |
| Heart failure | 0.82 (0.52–1.32) | 0.43 | 0.79 (0.49–1.24) | 0.33 |
| Vascular disease | 1.02 (0.57–1.83) | 0.92 | 1.11 (0.62–1.91) | 0.69 |
| History of stroke or TIA | 2.35 (1.52–3.63) | <0.001 | 1.01 (0.56–1.69) | 0.97 |
| New OAC use | 1.71 (1.08–2.70) | 0.021 | 1.28 (0.78–2.05) | 0.31 |
| Antiplatelet use | 1.00 (0.59–1.69) | 0.97 | 1.18 (0.70–1.94) | 0.50 |
| DOAC vs. warfarin | 1.06 (0.70–1.58) | 0.77 | 0.97 (0.65–1.45) | 0.91 |
| CrCl ≤ 50 mL/min | 1.68 (1.06–2.64) | 0.024 | 1.93 (1.23–3.02) | 0.004 |
| Third tertile of FIB4 index | 1.21 (0.81–1.80) | 0.33 | 1.31 (0.88–1.94) | 0.17 |
HR: hazard ratio; C.I.: confidence interval; FIB4: Fibrosis-4; Other abbreviations were previously defined in Table 1 footnote.