Table 4.
Evaluation of increased predictive ability of the Fibrosis-4 index to CHA2DS2-VASc score for prediction of cardiovascular events and all-cause mortality.
| Risk score | C-statistics (95% C.I.) |
p Value | NRI (95% C.I.) |
p Value | IDI (95% C.I.) |
p Value |
|---|---|---|---|---|---|---|
| Cardiovascular events | ||||||
| CHA2DS2-VASc score | 0.609 (0.574–0.644) | Ref. | Ref. | Ref. | ||
| CHA2DS2-VASc score+ FIB4 index | 0.638 (0.602–0.674) | 0.025 | 0.32 (0.19–0.45) | <0.001 | 0.010 (0.005–0.015) | <0.001 |
| All-cause mortality | ||||||
| CHA2DS2-VASc score | 0.626 (0.587–0.664) | Ref. | Ref. | Ref. | ||
| CHA2DS2-VASc score+ FIB4 index | 0.672 (0.636–0.709) | 0.001 | 0.40 (0.25–0.54) | <0.001 | 0.011 (0.005–0.018) | <0.001 |
NRI: net reclassification improvement; IDI: integrated discrimination improvement; Other abbreviations were previously defined in Table 1 footnote.