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. 2020 Jan 30;9(2):377. doi: 10.3390/jcm9020377

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Abeta42 levels in the saliva of 148 normal, 89 high normal (at risk), and 30 AD cases. Aβ levels of low controls, high controls, and AD were tested. Averages and SD were 21.26 ± 1.73 for low controls (148 cases), 37.96 ± 8.13 for high controls (89 cases), and 51.70 ± 10.50: p < 0.01 between low level control group, high level control group, and AD group and p < 0.05between high level control group and AD. (B) A reduction in salivary Abeta42 by administration of ibuprofen (dosage: 200 mg, twice a day). Case 1 in black showed 48.31 pg/mL in salivary Abeta42, which was reduced to normal in 44 days. In Case 2, salivary Abeta42 was 41.12 pg/mL. This was reduced in 34 days on ibuprofen. (C) Salivary Abeta42 levels were constant during the day. Three cases were examined.