Table 1.

Characteristics and endpoint definitions of included randomized trials.

Study	Year	Location	N	Study Design	Primary Endpoint	Mortality Reported	Valve Type	Randomization	Follow-Up (Years)
NOTION	2015	Multicenter	280	RCT	Death from any cause, stroke, or myocardial infarction	Yes	CoreValve (Medtronic)	TAVR vs. SAVR	1
ELRT	2019	Multicenter	1403	RCT	Death from any cause or disabling stroke	Yes	CoreValve, Evolut R, or Evolut PRO (Medtronic)	TAVR vs. SAVR	1
PARTNER 3	2019	Multicenter	950	RCT	death from any cause, stroke, or rehospitalization	Yes	Sapien 3 (Edwards)	TAVR vs. SAVR	1

Abbreviations: RCT = randomized clinical trials; TAVR = transcatheter aortic valve replacement; SAVR = surgical aortic valve replacement.