Table 1. SAR around β-PMTX Analogs^a.

^aSequence of amino acids indicated by one-letter code. Letters shown in red represent replaced amino acid residue. C* represents disulfide linkage between residues in peptides 6 and 7. Abbreviations: 1-Nal, 3-(1-naphthyl)-l-alanine; 2-Nal, 3-(2-naphthyl)-l-alanine; Phe(4-Cl), l-4-chlorophenylalanine. A dose–response curve was obtained on the Q-Patch using recombinant HEK-hNav1.1 cells. The values represent the area under the curve (AUC) and its standard error. The AUC ratio was calculated as (peptide AUC/baseline AUC).