Figure 2.
Mapping of the ECLE locus by genome-wide association. (A) Manhattan plot illustrating a single signal on chromosome 18. The dashed red line indicates the threshold for suggestive significance at p = 5 × 10−5 according to [29]. The best associated marker did not reach the stringent Bonferroni significance threshold (pBonf. = 4.3 × 10−7) due to several close relationships and extreme genomic inflation in the dataset. The genomic inflation factor was 1.90 before and 0.99 after the correction. (B) The quantile–quantile (QQ) plot shows the observed versus expected –log(p) values. The straight red line in the QQ plot indicates the distribution of p-values under the null hypothesis. The deviation of p-values at the right side indicates that these markers are stronger associated with the trait than would be expected by chance. This supports the biological significance of the association.