Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 5;9(2):428. doi: 10.3390/jcm9020428

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Oral ultramicronized palmitoylethanolamide (um-PEA) treatment rescues short-(3 h; panel A) and long-term (24 h; panel B) memory deficits in the 3×Tg-AD mice, as evaluated by novel object recognition test. Age-matched non-Tg mice and 3×Tg-AD mice (2 months ± 2 weeks of age) have been orally treated for 3 months with the compound (100 mg/kg/day, added to the animal food), while control animals were fed with a standard diet during the treatment period. Novel object recognition test was performed at the end of the treatment period. The data are presented as means ± SEM of 9–11 animals for each group. * p < 0.05 significantly different from the respective non-Tg mouse group; p < 0.05 significantly different from the respective PEA-treated group according to two-way ANOVA followed by Tukey multiple-comparison test.