Figure 5.

Effects of oral ultramicronized palmitoylethanolamide (um-PEA) treatment on reactive oxygen species (ROS) production in hippocampus homogenates from non-Tg and 3×Tg-AD mice. Age-matched non-Tg mice and 3×Tg-AD mice (2 months ± 2 weeks of age) have been orally treated for 3 months with the compound (100 mg/kg/day, added to the animal food), while control animals were fed with a standard diet during the treatment period. ROS production was measured in hippocampus tissues taken from mouse brains at the end of the treatment period. The data are presented as mean ± SEM (n = 5, in triplicate). * p < 0.05 significantly different from the other groups according to two-way ANOVA followed by Tukey multiple-comparison test.