Figure 7.

Oral ultramicronized palmitoylethanolamide (um-PEA) treatment rescues increased glutamate levels in the hippocampus of 3×Tg-AD mice. Age-matched non-Tg mice and 3×Tg-AD mice (2 months ± 2 weeks of age) have been orally treated for 3 months with the compound (100 mg/kg/day, added to the animal food), while control animals were fed with a standard diet during the treatment period. Microdialysis experiments were performed at the end of the treatment period. The data are presented as mean ± SEM of 6–7 animals/group. * p < 0.05, ** p < 0.01 significantly different from the respective non-Tg mouse group; p < 0.05 significantly different from the respective PEA-treated group according to two-way ANOVA followed by Tukey multiple-comparison test.