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Effect of M40 pan-antagonist of GalR1 and GalR2 on biliary hyperplasia and hepatic fibrosis in cholestatic and control mice. Expression of cytokeratin 19 (CK19; A), PCNA (B), α-smooth muscle actin (α-SMA; C), Col1A1 (D), MMP2 (E) and TIMP1 (F) mRNAs was assessed by real-time quantitative PCR in livers of FVBN and Mdr2KO mice treated with vehicle or M40. n = 4 (A-F). *P < 0.05 M40 versus vehicle; †P < 0.05 Mdr2KO versus FVBN.
