Table 4.

Predictors of the mild CCS (NIHSS ≤8 and LVEF ≥60%).

Severity of CCS	Univariate Analysis			Multivariate Analysis
Variables	OR	95% CI	p-Value	OR	95% CI	p-Value
Age per year	0.955	0.919–0.992	0.018
Age ≥65 years	0.386	0.166–0.900	0.027
Male sex	0.895	0.392–2.045	0.793
Smoker	2.200	0.900–5.378	0.084
Systolic blood pressure	1.012	0.998–1.027	0.100
Diastolic blood pressure	1.013	0.989–1.038	0.279
Hypertension	0.476	0.165–1.370	0.169
Diabetes mellitus	0.758	0.321–1.791	0.528
Dyslipidemia	2.588	1.112–6.024	0.027
Old myocardial infarction	1.577	0.138–18.004	0.714
Old stroke	0.420	0.147–1.200	0.105
Atrial fibrillation	0.141	0.029–0.694	0.016
RAS inhibitor	1.471	0.651–3.322	0.354
Statin	1.375	0.612–3.088	0.441
Leukocyte	0.945	0.815–1.096	0.457
Hemoglobin	1.136	0.928–1.390	0.218
Platelet	1.002	0.996–1.008	0.563
Creatinine	0.903	0.595–1.372	0.633
Total cholesterol	1.002	0.994–1.010	0.633
High-density lipoprotein	1.001	0.971–1.033	0.933
Low-density lipoprotein	0.998	0.989–1.007	0.655
Triglyceride	1.010	1.003–1.018	0.008
Mitral regurgitation (grade 2–4)	0.334	0.131–0.854	0.022
TLR2+/CD14+cells (%)	0.928	0.887–0.971	0.001
TLR2+/CD14+cells <25%	5.000	2.068–12.089	<0.001
TLR4+/CD14+cells (%)	1.048	0.857–1.281	0.650
TLR4+/CD14+cells <0.25%	3.143	1.332–7.416	0.009
Ly6G+/CD14+cells (%)	0.937	0.875–1.004	0.066
MPO+/CD14+cells (%)	0.926	0.889–0.964	<0.001
MPO+/CD14+cells <20%	3.846	1.600–9.246	0.003
IL33 (pg/mL)	0.980	0.841–1.143	0.801
sST2 (pg/mL)	1.000	1.000–1.000	0.002
sST2 <14,000 (pg/mL)	13.632	4.592–40.469	<0.001	12.743	3.836–42.328	<0.001

Abbreviation: CCS = cerebral-cardiac syndrome; NIHSS = National Institute of Health Stroke Scale; LVEF = left ventricular ejection fraction; OR = odds ratio; CI = confidence interval; RAS = renin-angiotensin-system; TLR = toll-like receptor; CD = cluster of differentiation; Ly6G = lymphocyte antigen 6 complex locus G6D; MPO = myeloperoxidase; IL33 = interleukin 33; sST2 = soluble suppression of tumorigenesis 2.