Table 3.
Results of univariable and multivariable logistic regression analysis for predicting the presence of any type of brain lesion. Multivariable corrections were applied for age and sex to each index separately. This was a pooled analysis of ARD patients and disease controls with and without brain involvement.
| Variable | Univariable Logistic Regression | Multivariable Logistic Regression | ||
|---|---|---|---|---|
| OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
| LVEDV (per 5 mL) | 0.98 (0.94–1.03) | 0.422 | 1.01 (0.96–1.06) | 0.817 |
| LVESV (per 5 mL) | 0.99 (0.93–1.06) | 0.844 | 1.03 (0.95–1.11) | 0.493 |
| LVEF (per 5%) | 1.01 (0.75–1.35) | 0.957 | 0.90 (0.65–1.25) | 0.525 |
| RVEDV (per 5 mL) | 0.98 (0.93–1.04) | 0.491 | 1.02 (0.96–1.09) | 0.519 |
| RVESV (per 5 mL) | 0.99 (0.89–1.10) | 0.823 | 1.07 (0.94–1.21) | 0.309 |
| RVEF (per 5%) | 0.97 (0.66–1.44) | 0.899 | 0.79 (0.49–1.28) | 0.337 |
| T2 signal ratio | 0.87 (0.28–2.65) | 0.801 | 0.60 (0.16–2.16) | 0.433 |
| EGE (%) | 0.98 (0.86–1.11) | 0.766 | 0.95 (0.83–1.09) | 0.474 |
| LGE (%) | 0.93 (0.83–1.05) | 0.27 | 0.93 (0.81–1.06) | 0.254 |
| Native T1-mapping (per 10 ms) | 1.01 (0.95–1.09) | 0.702 | 0.94 (0.86–1.02) | 0.169 |
| Post-contrast T1-mapping (per 10 ms) | 0.93 (0.85–1.03) | 0.168 | 0.94 (0.85–1.05) | 0.283 |
| ECV (%) | 1.11 (0.98–1.27) | 0.103 | 1.08 (0.96–1.21) | 0.197 |
| T2-mapping (ms) | 1.02 (0.95–1.10) | 0.53 | 0.98 (0.90–1.06) | 0.563 |
| ARD patients (compared with controls) | 9.10 (2.84–29.17) | <0.001 * | 6.26 (1.74–22.49) | 0.005 * |
ARD autoimmune rheumatic disease; LV-/RV left/right ventricular; EDV/ESV end-diastolic/-systolic volume; EF ejection fraction; EGE/LGE early/late gadolinium enhancement; ECV extracellular volume fraction. * p ≤ 0.05.