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Alpha- and delta storage pool disease (SPD) by immunofluorescence microscopy. Panel I. (A–F) In alpha SPD, the labeling for the alpha-granule markers thrombospondin (TS), P-selectin (P-sel), and von Willebrand factor (vWF) shows significantly reduced staining with respect to control. Panel II. (A–F) In delta SPD, the dense granule markers Lamp 1 (L1), Lamp 2 (L2), and CD63 display diffuse patterns with reduced or even absent granularity. Alpha- and delta SPD can present associated.
