Table 1.

Details of studies representing protein database structures of major targets in coronavirus and their structures

PDB ID	Details	Inhibitor	IC50	Reference
N protein
4KXJ	Interaction between PJ34 and NTD of N protein of HCoV-OC43	PJ34	-	[26]
3V3P	Structure not released			[30]
4LM7	Interactions of NTD of N protein of HCoV-OC43 with UMP	-		[26]
4LI4	Interactions of NTD of N protein of HCoV-OC43 with AMP	-		[26]
Protease
4TWY	3CLPro of SARS-CoV with an inhibitor	3BL		[27]
4TWW	3CLPro of SARS-CoV with an inhibitor	41	63 µM	[27]
4WY3	3CLPro of SARS-CoV with an inhibitor	3X5	240 µM	[27]
4OVZ	CoV PLPro complexed with inhibitor	P85	490 nM	[31]
3MJ5	SARS-CoV PLPro complexed with inhibitor	GRM	320 nM	[32]
2FE8	SARS-CoV PLPro	-	-	[33]
1UK4	SARS-CoV 3CLPro and its interactions with an inhibitor	Substrate analog hexapeptidyl CMK inhibitor	IC50 ca. 2 mM	[34]
1UJ1, 1UK3, 1UK2	SARS-CoV M-pro, apo-enzyme at different pH	-	-	[34]
3VB6	SARS-CoV 3CLPro in complex with C6Z	C6Z	39 µM	[35]
3VB5	SARS-CoV 3CLPro with C4Z	C4Z	1.3-4.6 µM	[35]
3TLO	HCoV-NL63 3CLPro	-	-	[36,37]
6LU7	Main protease of 2019-nCoV and its complex with N3 (inhibitor)	-	-	[38]
Spike protein
5ZUV	HR1 motif of HCoV-229E in complex with EK1	Modified OC43-HR2P peptide (EK1)	0.19-0.62 µM	[39]
5ZVM	EK1 in complex with SARS HR1 motif			[39]
5X4S	NTD of SARS-CoV S protein			[40]
5WRG	SARS-CoV S protein			[41]
6Q05	MERS-CoV S structure in complex with Sialyl-Lewis			[42]
6ACG	SARS-CoV S protein: ACE-2 (conformation 1) complex			[43]
6ACK	SARS-CoV S protein: ACE-2 (conformation 3) complex			[43]
3SCI	RBD of S protein interaction with ACE-2			[44] to be published

NTD=N-terminal domain, CoV=Coronovirus, 3CLPro=3C-like protease, PL^pro=Papain-like protease, MERS=Middle East respiratory syndrome, SARS=Severe acute respiratory syndrome, ACE-2=Angiotensin converting enzyme-2, RBD=Receptor-binding domain, nCoV=Novel coronavirus, S protein=Spike protein