Table 3.

Predictive value of “classic” biomarkers in the general population.

General Population	Biomarker	Underlying Condition	Arrhythmias	Outcome	Number of Patients	Study Design	FU-Duration	Specific Endpoint	Effect on SCD
Hussein et al., 2013 [24]	CRP, IL-6	Adults aged 65 years or older	SCD	CRP and IL-6 are associated with SCD	5888	Subgroup analysis of prospective multicenter (Cardiovascular Health Study)	17 years (median 13.1 years)	SCD	Factor associated with SCD
Albert et al., 2002 [21]	hsCRP	Healthy men	SCD	Associated with SCD	97	Sub-study, prospective (Physician`s Healthy Study)	17 years	SCD	Factor associated with SCD
Korngold et al., 2009 [77]	NT-proBNP, hsCRP	Healthy women	SCD	Associated with SCD	32 828	Prospective, nested, case-control study	16 years	SCD	Factor associated with SCD
Hussein et al., 2013 [81]	hs-TnT	Ambulatory participants	SCD	Associated with SCD	4 431	Subgroup analysis of prospective multicenter (Cardiovascular Health Study)	13.1 years	SCD	Factor associated with SCD

AMI, acute myocardial infarction; CRP, C-reactive protein; hsCRP, high-sensitive C-reactive protein; IL-6, Interleukin 6; NT-proBNP, N-terminal pro-B-type natriuretic peptide; SCD, sudden cardiac death; VF, ventricular fibrillation; VT, ventricular tachycardia.