Table 1.
Significant changes in cortical metabolites of non-Tg (WT) and rTg4510 mice. Cortices from four months-old WT (n = 20) and rTg4510 (n = 16) mice were evaluated. Data are presented as mean ± SD of µmol/mg tissue; p-value represents significance.
| Metabolite | WT | rTg4510 | t.stat | p-Value | FDR |
|---|---|---|---|---|---|
| Glycerophospholipids | |||||
| PC aa C30:0 | 3.71 ± 0.54 | 2.47 ± 0.45 | −7.5081 | <0.0001 | 0.0000012 |
| PC aa C32:0 | 101.9 ± 22.4 | 75.5 ± 15.0 | −3.2926 | 0.0023 | 0.0144960 |
| PC ae C32:1 | 1.66 ± 0.28 | 1.11 ± 0.147 | −8.0568 | <0.0001 | 0.0000005 |
| PC aa C42:4 | 0.146 ± 0.02 | 0.113 ± 0.018 | −5.0941 | <0.0001 | 0.0002996 |
| PC aa C32:3 | 0.228 ± 0.050 | 0.178 ± 0.022 | −3.3024 | 0.0023 | 0.0144960 |
| PC aa C34:1 | 146.9 ± 9.2 | 136.9 ± 7.1 | −3.577 | 0.0011 | 0.0082230 |
| PC aa C36:6 | 0.295 ± 0.037 | 0.239 ± 0.045 | −4.0477 | 0.0003 | 0.0032613 |
| PC ae C32:2 | 0.183 ± 0.037 | 0.143 ± 0.015 | −4.4828 | 0.0001 | 0.0014143 |
| PC aa C36:0 | 1.66 ± 0.94 | 0.815 ± 0.266 | −4.3839 | 0.0001 | 0.0017034 |
| PC ae C30:0 | 0.144 ± 0.024 | 0.118 ± 0.011 | −4.2498 | 0.0002 | 0.0021383 |
| PC ae C34:0 | 1.23 ± 0.35 | 0.687 ± 0.244 | −4.9941 | <0.0001 | 0.0003672 |
| PC ae C34:3 | 0.154 ± 0.025 | 0.13 ± 0.026 | −2.9554 | 0.0056 | 0.0264610 |
| PC ae C36:0 | 0.358 ± 0.075 | 0.296 ± 0.036 | −3.1638 | 0.0033 | 0.0171870 |
| PC aa C36:1 | 62.9 ± 10.3 | 51.1 ± 5.4 | −4.2241 | 0.0002 | 0.0021763 |
| PC ae C34:1 | 9.87 ± 2.93 | 7.33 ± 0.62 | −4.0578 | 0.0003 | 0.0032613 |
| PC aa C42:5 | 0.180 ± 0.039 | 0.141 ± 0.020 | −3.8824 | 0.0005 | 0.0044484 |
| PC aa C36:2 | 41.7 ± 7.9 | 34.1 ± 3.8 | −3.8131 | 0.0006 | 0.0050945 |
| PC aa C38:0 | 0.340 ± 0.044 | 0.301 ± 0.036 | −2.9493 | 0.0057 | 0.0264610 |
| PC ae C30:1 | 0.047 ± 0.012 | 0.038 ± 0.008 | −2.9132 | 0.0063 | 0.0284540 |
| PC ae C36:1 | 3.54 ± 1.56 | 2.52 ± 0.46 | −2.8434 | 0.0075 | 0.0333190 |
| PC aa C28:1 | 0.093 ± 0.026 | 0.0763 ± 0.007 | −2.7483 | 0.0095 | 0.0399800 |
| Amino acids | |||||
| Arg | 11.1 ± 3.1 | 15.8 ± 4.3 | 3.8875 | 0.0004 | 0.0044484 |
| Asn | 24.7 ± 2.8 | 19.4 ± 2.5 | −5.9583 | 0.00001 | 0.0000563 |
| Gln | 1739 ± 295 | 2162 ± 435 | 3.379 | 0.0018 | 0.0123810 |
| Tau | 579 ± 29 | 541 ± 22 | −4.3707 | 0.0001 | 0.0017034 |
| Leu | 14.3 ± 4.0 | 20.0 ± 7.2 | 3.2244 | 0.0028 | 0.0153300 |
| Pro | 23.4 ± 3.8 | 27.4 ± 4.8 | 2.7764 | 0.0089 | 0.0379620 |
| Trp | 5.56 ± 1.21 | 6.90 ± 1.77 | 2.6795 | 0.0113 | 0.0457270 |
| Val | 26.3 ± 4.4 | 31.4 ± 6.8 | 2.7782 | 0.0088 | 0.0379620 |
| Hist | 2.18 ± 0.57 | 3.0 ± 0.78 | 3.4083 | 0.0017 | 0.0118830 |
| Biogenic Amines | |||||
| Putrescine | 1.26 ± 0.20 | 1.65 ± 0.51 | 3.0893 | 0.0040 | 0.0191700 |
| Serotonin | 1.33 ± 0.26 | 1.66 ± 0.32 | 3.3716 | 0.0019 | 0.0123810 |
| Sphingolipids | |||||
| SM OH C16:1 | 0.220 ± 0.038 | 0.154 ± 0.024 | −6.3622 | <0.0001 | 0.0000225 |
| SM OH C22:1 | 0.090 ± 0.038 | 0.059 ± 0.020 | −3.5462 | 0.0012 | 0.0086668 |
| SM OH C22:2 | 0.122 ± 0.091 | 0.066 ± 0.012 | −3.1426 | 0.0035 | 0.0174490 |
| SM OH C24:1 | 0.134 ± 0.020 | 0.112 ± 0.021 | −3.1212 | 0.0037 | 0.0180030 |
| SM C26:1 | 0.05 ± 0.03 | 0.032 ± 0.015 | −2.7332 | 0.0099 | 0.0407570 |
| SM C18:0 | 30.4 ± 8.2 | 20.8 ± 5.2 | −3.6524 | 0.0009 | 0.0074096 |
| SM C20:2 | 0.123 ± 0.029 | 0.091 ± 0.024 | −3.603 | 0.0010 | 0.0079330 |
| Acylcarnitines | |||||
| C3-OH | 0.181 ± 0.02 | 0.2 ± 0.016 | 3.2767 | 0.0024 | 0.0147300 |
| C4:1 | 0.016 ± 0.002 | 0.019 ± 0.003 | 3.1925 | 0.0030 | 0.0162960 |