Table 2.
Correlation between metabolites and the percentage of path in target. The animals used for these analyses were 4 months-old WT (n = 20) and rTg4510 (n = 16) mice. ρ represents Pearson’s correlation coefficient; p-value represents significance.
| Metabolite | lysoPC a C16:0 | lysoPC a C17:0 | PC aa C30:0 | PC aa C32:0 | PC aa C32:2 | PC aa C32:3 | PC aa C34:1 | PC aa C36:6 | PC aa C42:4 | PC ae C32:1 | PC ae C34:0 | PC ae C36:0 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Path in target | ρ | −0.423 | −0.422 | 0.477 | 0.451 | 0.348 | 0.358 | 0.346 | 0.358 | 0.447 | 0.449 | 0.499 | 0.468 |
| p -value | 0.010 | 0.010 | 0.003 | 0.006 | 0.038 | 0.032 | 0.039 | 0.032 | 0.006 | 0.006 | 0.002 | 0.004 | |
| Amino acids | Ala | Asn | Gln | Met | Orn | ||||||||
| % Path in target | ρ | 0.404 | 0.387 | −0.443 | 0.35 | −0.354 | |||||||
| p -value | 0.014 | 0.020 | 0.007 | 0.037 | 0.034 | ||||||||
| Biogenic amines | Ac-Orn | Putrescine | Serotonin | ||||||||||
| % Path in target | ρ | −0.338 | −0.49 | −0.54 | |||||||||
| p -value | 0.044 | 0.002 | 0.001 | ||||||||||
| Sphyngolipids | SM (OH) C16:1 | SM C18:0 | |||||||||||
| % Path in target | ρ | 0.415 | 0.44 | ||||||||||
| p -value | 0.012 | 0.007 | |||||||||||
| Acylcarnitines | C10:1 | C10:2 | C16:2 | C5-OH (C3-DC-M) | C5:1-DC | ||||||||
| % Path in target | ρ | −0.376 | 0.348 | −0.378 | −0.363 | 0.336 | |||||||
| p -value | 0.024 | 0.037 | 0.023 | 0.030 | 0.045 | ||||||||