Fig. 3.
Suppression of BMPR2 expression in macrophages contributes to pulmonary vascular remodeling in mouse model of PH: (a) Number of muscularized vessels in lung. Black bar = 0–25 uM, white bar = 25–50 uM, and gray bar = 50–100 uM size vessels. *P < 0.05 control (PBS) vs. Rosa26delx4 (PBS), $P < 0.05 Rosa26delx4 (PBS) vs. Rosa26delx4 (clodronate), @P < 0.05 control (sugen/hypoxia) vs. BMPR2Het and BMPR2KO, #P < 0.05 BMPR2Het (sugen/hypoxia) vs. and BMPR2KO (sugen/hypoxia); and (b) Immunofluorescence staining for smooth muscle actin in green (magnification 100×).