Fig. 5.

Vasular and hypoxic injury increases proinflammatory cytokines in circulation and lung in monocytic lineage-specific BMPR2 KO mice: (a–c) Dot blot depicting cytokine profile in circulation, lung and bone marrow-derived macrophages (BMDM). (d–f) Bar graph representing fold increase in cytokines C5a, CXCL12, sICAM, and IL-16 in circulation, lung, and BMDM. Control mice are LysM Cre mice and BMPR2^KO mice are LysM Cre BMPR2-KO mice. *P < 0.01 BMPR2^KO vs. controls, #P < 0.01 controls at baseline vs. sugen/hypoxia, ^P < 0.01 BMPR2^KO at baseline vs. sugen/hypoxia, $P < 0.01 control at baseline vs. with IL6 treatment, and @P < 0.01 BMPR2^KO at baseline vs. with IL6 treatment.