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. 2020 Feb 18;11(2):211. doi: 10.3390/genes11020211

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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miRome analysis reveal up-regulated expression of miR-29 and miR-let-7 family members in the kidneys of ACE inhibitor or combination treated diabetic mice. (A) microRNA-array analysis in the diabetic group vs ACEi + AcSDKP treatment in diabetic mice revealed alteration in the expression level of pro and antifibrotic microRNAs. N = 3 were analyzed in each group. (B) miR-29 and miR-let-7 family members emerged as important regulatory antifibrotic molecules and validation by the real time PCR using specific primers in the kidney of control, DM, ACEi, combination treatment and ARB group. N = 6 were analyzed in each group. Hs_RNU6 was used as internal control to normalize the expression data. Data in the graph are presented as mean±SEM. One-way Anova Tukey test was performed for calculation of statistical significance.